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2021 DORIS definition of remission in SLE: final recommendations from an international task force
Ronald F van Vollenhoven1, George Bertsias2, Andrea Doria3
1Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam, The Netherlands r.vanvollenhoven@amsterdamumc.nl.
Objective:
To achieve consensus on a definition of remission in SLE (DORIS).
Background:
Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.
Methods:
Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.
Results:
Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0-3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.
Conclusion:
The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.
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