Related Experiment Video
Updated: Oct 12, 2025

04:27
Intratracheal Instillation of Stem Cells in Term Neonatal Rats
Published on: May 4, 2020
5.8K
New Warning About Treating Children with Short-Term Corticosteroid Bursts
The American Journal of Nursing
|November 25, 2021
Summary
Researchers are urging caution with commonly prescribed drugs once thought to be harmless. New findings suggest potential risks, necessitating a reevaluation of their widespread use in medical practice.
Area of Science:
- Pharmacology
- Clinical Medicine
- Drug Safety
Background:
- Certain medications, previously regarded as safe, are now under scrutiny.
- Emerging research indicates potential adverse effects associated with these drugs.
Discussion:
- The long-standing perception of safety for these drugs is being challenged.
- A critical review of prescribing guidelines is warranted based on new evidence.
Key Insights:
- Previously underestimated risks associated with common pharmaceuticals are being identified.
- Medical professionals should exercise increased vigilance when prescribing these agents.
Outlook:
- Future research will focus on elucidating the mechanisms behind these newly recognized risks.
- Clinical practice guidelines may need revision to reflect updated safety profiles.
Related Concept Videos
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
444
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
444
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
238
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
238
COPD: Management Using Bronchodilators and Corticosteroids
466
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
466
Drug Dosing: Infants and Children
35
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
35
Pharmacokinetics in Pediatric Patients: Drug Excretion
22
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
22
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
546
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
546

