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Updated: Oct 12, 2025
04:41
Knee Arthrocentesis in Adults
Published on: February 25, 2022
8.1K
Injectable therapies for knee osteoarthritis.
1Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Australia.
Reumatologia
|November 25, 2021
Summary
Corticosteroid injections offer the strongest evidence for knee osteoarthritis relief. Hyaluronic acid and platelet-rich plasma injections also show promise for long-term pain management in knee arthritis.
Area of Science:
- Orthopedics
- Rheumatology
- Regenerative Medicine
Background:
- Knee osteoarthritis (OA) is a degenerative joint disease causing pain and disability, primarily in older adults.
- Current treatments aim to manage pain and functional decline, with surgery as a last resort due to risks and patient eligibility.
- Non-operative options are available, but clinical guidelines offer varied recommendations.
Purpose of the Study:
- To review recent randomized controlled trials and meta-analyses on non-operative injectable treatments for knee osteoarthritis.
- To evaluate the evidence for corticosteroids, hyaluronic acid (HA), platelet-rich plasma (PRP), mesenchymal stem cells, and ozone therapy.
Main Methods:
- Systematic review of randomized controlled trials and meta-analyses.
- Analysis of injectable treatments including corticosteroids, HA, PRP, stem cells, and ozone therapy.
Main Results:
- Corticosteroid injections demonstrate the strongest current evidence for efficacy in knee OA.
- Hyaluronic acid (HA) and platelet-rich plasma (PRP) injections show promising results for long-term symptom relief.
- Evidence for mesenchymal stem cells and ozone therapy is still emerging.
Conclusions:
- Corticosteroid injections are a well-supported treatment option for knee OA.
- HA and PRP injections represent promising alternatives with potential for sustained benefits.
- Further research is needed to fully elucidate the long-term efficacy and optimal use of emerging regenerative therapies.
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