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Cardiac Biomarkers in COVID-19: A Narrative Review

Giuseppe Lippi1, Fabian Sanchis-Gomar2, Brandon Michael Henry3

  • 1Section of Clinical Biochemistry, University of Verona, Verona, Italy.

EJIFCC
|November 25, 2021
PubMed

Insights

Cardiac biomarkers are crucial for managing COVID-19 patients. Assessing cardiac injury and dysfunction aids in risk stratification for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, improving patient outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Clinical Laboratory Science

Background:

  • Cardiovascular disease is a frequent complication and risk factor for severe outcomes in COVID-19.
  • Pre-existing cardiovascular conditions exacerbate COVID-19 morbidity, disability, and mortality.
  • Current COVID-19 diagnosis and risk stratification rely heavily on laboratory resources.

Purpose of the Study:

  • To review cardiac involvement in patients with SARS-CoV-2 infection.
  • To provide the clinical rationale for incorporating cardiac biomarkers into COVID-19 management protocols.
  • To highlight the role of cardiac biomarkers in risk stratification.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of evidence linking cardiovascular disease and COVID-19 severity.
  • Examination of the utility of cardiac biomarkers in patient management.

Main Results:

  • Cardiac injury and dysfunction are common in moderate to critical COVID-19.
  • Biomarkers like cardiac troponin and natriuretic peptides are essential for assessing cardiac status.
  • Pre-existing cardiovascular disease significantly increases adverse COVID-19 outcomes.

Conclusions:

  • Routine assessment of cardiac biomarkers is vital for managing COVID-19 patients.
  • Cardiac biomarker testing aids in risk stratification and clinical decision-making.
  • Integrating cardiac biomarkers into laboratory panels improves COVID-19 patient care.

Keywords:
COVID-19SARS-CoV-2cardiac biomarkerscardiac troponinnatriuretic peptides

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