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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
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Glymphatic Dysfunction in Patients With Ischemic Stroke.

Cheng Hong Toh1,2, Tiing Yee Siow1

  • 1Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Frontiers in Aging Neuroscience
|November 25, 2021
PubMed
Summary
This summary is machine-generated.

Glymphatic function, measured by the ALPS index, is impaired in ischemic stroke patients. This impairment may recover over time, as the ALPS index increases with the time since stroke onset.

Keywords:
ALPS (analysis along perivascular space) indexdiffusion tensor imagingglymphatic functionischemic strokeneuroimaging biomarkers

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Area of Science:

  • Neuroscience
  • Radiology
  • Medical Imaging

Background:

  • Rodent studies suggest glymphatic dysfunction in ischemic stroke.
  • Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) enables noninvasive glymphatic system assessment in patients.

Purpose of the Study:

  • Investigate glymphatic function changes in ischemic stroke using DTI-ALPS.
  • Identify factors associated with altered glymphatic function post-stroke.

Main Methods:

  • Retrospective analysis of 50 ischemic stroke patients and 44 healthy controls.
  • Calculated the Analysis along the Perivascular Space (ALPS) index using preoperative diffusion-tensor imaging.
  • Assessed interhemispheric ALPS index differences and normalized ratios, adjusting for age and sex.

Main Results:

  • Ischemic stroke patients exhibited significantly lower ALPS index values on the infarct side compared to the contralateral side.
  • ALPS index ratios were significantly lower in stroke patients than in normal subjects.
  • Time since stroke onset was the sole factor associated with ALPS index values.

Conclusions:

  • The ALPS index is reduced in ischemic stroke, indicating impaired glymphatic function.
  • Glymphatic function appears to recover over time, as evidenced by increasing ALPS index values with time since stroke onset.