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Related Concept Videos

Brain Imaging01:14

Brain Imaging

384
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
384

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Related Experiment Video

Updated: Oct 12, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming.

Florian Lange1, Frank Steigerwald1, Tobias Malzacher1

  • 1Department of Neurology, University Hospital and Julius-Maximilians-University, Wuerzburg, Germany.

Frontiers in Neurology
|November 25, 2021
PubMed
Summary
This summary is machine-generated.

Image-guided deep brain stimulation (DBS) programming for Parkinson's disease (PD) significantly reduces setup time. This method maintains motor symptom control and patient satisfaction compared to standard programming.

Keywords:
Parkinson's diseasechronic stimulationdirectional deep brain stimulationimage-guided programmingrandomized controlled double-blind studysubthalamic nucleus

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Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Imaging

Background:

  • Deep brain stimulation (DBS) programming relies on clinical response testing.
  • Current methods can be time-consuming and subjective.

Purpose of the Study:

  • To assess the feasibility of image-guided DBS programming using patient-specific anatomical models.
  • To compare anatomical-based programming (ABP) with standard clinical-based programming (CBP) in Parkinson's disease patients.

Main Methods:

  • A pilot feasibility trial involving Parkinson's disease patients with subthalamic nucleus-DBS.
  • Randomized crossover design comparing CBP and ABP over 8 weeks.
  • Evaluation of programming characteristics and clinical outcomes (MDS-UPDRS III).

Main Results:

  • Both CBP and ABP achieved similar motor symptom control (MDS-UPDRS III scores).
  • Anatomical-based programming (ABP) significantly reduced programming time (19.78 min vs. 45.22 min).
  • No significant differences in time spent programming or stimulation settings, except for frequency.

Conclusions:

  • Image-guided DBS programming is feasible and drastically reduces programming time in Parkinson's disease.
  • This approach does not compromise symptom control or patient satisfaction.
  • Further feasibility studies are warranted for image-guided DBS programming.