Related Experiment Video

Updated: Oct 12, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K

Co-relation Between Calcium-Phosphorus Product and Hypertension in End-Stage Renal Disease Patients

Faiza Anser1, Murtaza Dhrolia1, Kiran Nasir1

  • 1Nephrology, The Kidney Centre Hospital, Karachi, PAK.

Cureus
|November 25, 2021
PubMed

Insights

The calcium-phosphorus product and high phosphorus levels are linked to blood pressure changes in hemodialysis patients. This association was observed for systolic, diastolic, and mean arterial pressure, but not pulse pressure.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Maintaining mineral and bone disorder balance is crucial in hemodialysis (HD) patients.
  • The calcium-phosphorus (Ca-P) product is a key indicator of mineral metabolism.
  • Elevated Ca-P product is associated with cardiovascular complications in chronic kidney disease.

Purpose of the Study:

  • To investigate the relationship between the Ca-P product and pre- and post-dialysis blood pressure (BP) parameters in HD patients.
  • To determine the independent effect of serum calcium, phosphorus, and parathyroid hormone on BP.
  • To identify potential markers for BP management in HD populations.

Main Methods:

  • Prospective, observational, cross-sectional study.
  • 111 patients undergoing maintenance HD for over six months were enrolled.
  • Linear regression analysis was used to assess correlations between Ca-P product and BP parameters (SBP, DBP, MAP, pulse pressure).

Main Results:

  • The Ca-P product showed strong correlations with pre-dialysis diastolic BP (0.7) and post-dialysis mean arterial pressure (0.7).
  • Moderate correlations were found with systolic BP and mean arterial pressure, both pre- and post-dialysis.
  • Serum phosphorus levels, independently, significantly correlated with systolic BP, diastolic BP, and mean arterial pressure.

Conclusions:

  • A significant association exists between the Ca-P product and pre- and post-dialysis blood pressure (SBP, DBP, MAP) in hemodialysis patients.
  • Elevated serum phosphorus levels independently impact blood pressure parameters in this cohort.
  • The Ca-P product and serum phosphorus are not associated with pulse pressure variations.

Keywords:
blood pressurecalcium-phosphorus productchronic kidney diseasehemodialysishypertension

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

938
Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
106
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
26
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
147
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
146
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
77
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.3K