Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Public Health Response to Imported Hansen's Disease Cases and Contact Investigation Findings in the Chungcheong Region, 2024-2025.

Public health weekly report·2026
Same author

Proton Pump Inhibitor Use and Clinical Outcomes in Atrial Fibrillation During Anticoagulation.

Journal of clinical medicine·2026
Same author

Development and Evaluation of a Quadrant Silicon Pad Sensor for the TexAT Active Target Detector.

Sensors (Basel, Switzerland)·2026
Same author

Developing aluminum molecular plating for neutron-induced reaction target fabrication.

Scientific reports·2026
Same author

Development of an in vitro method for simultaneous evaluation of androgenic activity of chemicals and their metabolites using S9: Application in biocides.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

Secondary transmission of severe fever with thrombocytopenia syndrome in a hospital setting in Republic of Korea: a retrospective observational study of personal protective equipment use and infection risk factors.

Osong public health and research perspectives·2026

Related Experiment Video

Updated: Oct 12, 2025

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation
11:10

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation

Published on: July 6, 2022

2.4K

Altered inflammatory response in FMRP-deficient microglia.

Jennifer M Parrott1, Thomas Oster1, Hye Young Lee1

  • 1The Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Iscience
|November 25, 2021
PubMed
Summary

Fragile X syndrome (FXS) involves genetic and environmental factors. FXS microglia show heightened inflammation and immune responses when exposed to LPS, indicating a gene-environment interaction.

Keywords:
ImmunologyMolecular biologyNeuroscience

More Related Videos

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.3K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

605

Related Experiment Videos

Last Updated: Oct 12, 2025

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation
11:10

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation

Published on: July 6, 2022

2.4K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.3K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

605

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Fragile X syndrome (FXS) is an inherited intellectual disability often co-occurring with autism spectrum disorders.
  • Genetic factors in FXS may increase susceptibility to environmental influences that worsen symptoms.
  • The interaction between genetic and environmental risk factors in FXS is not well understood.

Purpose of the Study:

  • To investigate the interaction between Fragile X syndrome genetics and environmental factors, specifically inflammation.
  • To examine the role of microglia, the brain's immune cells, in this gene-environment interaction.

Main Methods:

  • Utilized Fmr1 knock-out (KO) mice, a model for FXS.
  • Administered lipopolysaccharide (LPS), an immune stimulus, to Fmr1 KO and wild-type (WT) microglia.
  • Assessed inflammatory and phagocytic responses, mitochondrial function, and morphology.

Main Results:

  • Fmr1 KO microglia exhibited elevated pro-inflammatory and phagocytic responses to LPS compared to WT microglia.
  • Baseline differences in mitochondrial function and morphology were observed between Fmr1 KO and WT microglia.
  • LPS treatment exacerbated these mitochondrial differences in Fmr1 KO microglia.

Conclusions:

  • Fmr1 KO microglia display an altered inflammatory mechanism.
  • These findings suggest a significant gene and environment interaction in the context of Fragile X syndrome.
  • Microglia play a crucial role in the exacerbated inflammatory response observed in the FXS model.