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Relapsing Klebsiella pneumoniae meningitis in a patient with COVID-19

N Ronan1, M Jackson2, V Juhasz2

  • 1Department of Medical Education Stockport Foundation Trust Stockport UK.

Anaesthesia Reports
|November 25, 2021
PubMed

Insights

A patient with COVID-19 and corticosteroid treatment developed recurrent Klebsiella pneumoniae meningitis. Early detection and treatment are crucial for managing opportunistic infections in immunocompromised COVID-19 patients.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Critical Care Medicine

Background:

  • Klebsiella pneumoniae is a significant cause of severe bacterial infections.
  • Corticosteroid therapy and SARS-CoV-2 infection can increase susceptibility to opportunistic pathogens.
  • Healthcare-associated infections pose a challenge in hospitalized patients.

Observation:

  • A 60-year-old patient with COVID-19 pneumonitis and on corticosteroids developed bacterial meningitis.
  • Klebsiella pneumoniae was identified as the causative agent in cerebrospinal fluid and blood cultures.
  • The patient experienced a relapse of meningitis shortly after initial treatment and discharge.

Findings:

  • Relapsing Klebsiella pneumoniae meningitis occurred in an immunocompromised COVID-19 patient.
  • Despite initial meropenem treatment, the infection recurred, leading to patient deterioration.
  • Cerebrospinal fluid analysis confirmed persistent Klebsiella pneumoniae infection upon re-admission.

Implications:

  • COVID-19 patients on immunosuppressive therapy require vigilant monitoring for opportunistic infections like meningitis.
  • Prompt diagnosis and aggressive antimicrobial treatment are vital for improving outcomes in such cases.
  • This case underscores the importance of considering serious bacterial infections in immunocompromised patients presenting with neurological symptoms.
Keywords:
COVID‐19corticosteroidsmeningitissepsis

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