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EGFR transactivates RON to drive oncogenic crosstalk

Carolina Franco Nitta1, Ellen W Green1, Elton D Jhamba1

  • 1Department of Pathology, University of New Mexico, Albuquerque, United States.

Elife
|November 25, 2021
PubMed
Summary

Receptor tyrosine kinase (RTK) crosstalk, specifically between EGFR and RON, is unidirectional. Epidermal Growth Factor Receptor (EGFR) directly phosphorylates Receptor Orf virus protein Non-fibrous (RON), activating its signaling pathway.

Keywords:
EGFRRONcell biologycell signalinghumanmembrane biophysicsmolecular biophysicsreceptor tyrosine kinasestructural biology

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