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Microfluidic Raman Sensing Using a Single Ring Negative Curvature Hollow Core Fiber
Xinyu Wang1,2,3, Shuguang Li1, Shoufei Gao4
1State Key Laboratory of Metastable Materials Science & Technology, Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China.
Biosensors
|November 25, 2021
Summary
A new microfluidic Raman system uses a novel hollow-core fiber for in-line biochemical analysis. This robust device offers high repeatability for bioprocessing monitoring.
Area of Science:
- Analytical Chemistry
- Optical Engineering
- Biotechnology
Background:
- Microfluidic systems are crucial for real-time biochemical analysis.
- Raman spectroscopy offers non-destructive chemical identification.
- Integrating these technologies requires efficient light delivery and sample handling.
Purpose of the Study:
- To develop a compact microfluidic Raman detection system.
- To enable in-line qualitative and quantitative analysis of biochemicals.
- To demonstrate the system's utility in bioprocessing monitoring.
Main Methods:
- A single-ring negative-curvature hollow-core fiber was utilized.
- Efficient light coupling was achieved using a short solid-core fiber within a ceramic ferrule.
- Continuous liquid injection was implemented for sample delivery.
Main Results:
- Over 50% coupling efficiency from excitation laser to hollow-core fiber was obtained.
- The system demonstrated in-line analysis of ethanol and glucose solutions.
- A limit of detection of ~0.04 vol.% for ethanol was achieved.
Conclusions:
- The developed all-fiber microfluidic device is robust and reusable.
- It provides highly repeatable Raman measurements.
- The system is well-suited for in-line monitoring of bioprocesses.
