Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering.

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Oncology

Background:

• Advances in liquid biopsy and oncological imaging have improved cancer diagnosis and care.
• Surface-enhanced Raman scattering (SERS) offers high sensitivity for molecular detection.
• SERS is applicable to early tumor detection, characterization, and monitoring.

Purpose of the Study:

• To review recent developments and trends in SERS applications for liquid biopsy and tumor imaging.
• To emphasize the clinical utility of SERS in oncology.
• To explore SERS for in vivo tumor targeting and drug release monitoring.

Main Methods:

• Review of recent scientific literature on SERS applications in liquid biopsy and tumor imaging.
• Critical analysis of studies demonstrating clinical utility.
• Focus on SERS techniques for biomarker detection and in vivo imaging.

Main Results:

• SERS provides single-molecule detection sensitivity, beneficial for cancer biomarker identification.
• Emerging SERS applications include in vivo tumor imaging and drug release monitoring.
• Several SERS-based approaches show promise for clinical application in oncology.

Conclusions:

• SERS is a powerful technique with significant potential to advance liquid biopsy and oncological imaging.
• Further research and development are needed to fully realize the clinical utility of SERS in cancer care.
• SERS-based diagnostics and monitoring could lead to more personalized and effective cancer treatments.