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Updated: Oct 12, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
The relationship between oral cancer and cadmium: a review
1Faculty of Dentistry, Oral and Maxillofacial Radiology, Alanya Alaaddin Keykubat University, Konaklı, Mustafa Kemal Boulevard, Alanya, 07490, Antalya, Turkey. samed.satir@alanya.edu.tr.
Abstract:
Cadmium (Cd) has been classified as a type I carcinogen. Since it is ingested orally through food and tobacco use, Cd is likely to be closely related to oral cancers. The relationship between cadmium and oral cancer was investigated using papers on Pubmed and Web of Science. Thus a total of 11 studies from these databases were included in the review. Cd concentrations were significantly higher in both the blood and hair of oral cancer patients than in controls. Additionally, it has been reported that Cd increases the activity of reactive oxygen species. Tobacco plants contain varying levels of Cd. The presence of high Cd concentrations in patients who use tobacco products and develop oral cancer is strong evidence that Cd is directly related to oral cancer. While planning a study to determine the Cd concentrations in biological samples, it is advisable to examine the methodologies of previous studies and to avoid technical deficiencies. New cell line studies are required to explain the relationship between Cd and autophagy-apoptosis.
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