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Proteomic analysis identified potential age-associated prognostic biomarkers in pneumonia-derived paediatric sepsis

Ting Luo1, Haipeng Yan2, Xun Li1

  • 1Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, China.

Proteomics. Clinical Applications
|November 25, 2021
PubMed

Insights

Plasma protein profiles differ between infants and toddlers with pneumonia-derived sepsis. Specific proteins like HP, THBS1, and SAA1/2 may serve as prognostic markers for poor outcomes in infants.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Immunology

Background:

  • Sepsis is a life-threatening condition with varying outcomes in pediatric patients.
  • Pneumonia-induced sepsis presents unique challenges in infants and toddlers.
  • Accurate prognostic markers are crucial for timely intervention and improved survival rates.

Purpose of the Study:

  • To investigate age-specific plasma protein profiles in pediatric sepsis originating from pneumonia.
  • To identify potential biomarkers that predict poor outcomes in infants and toddlers with pneumonia-derived sepsis.
  • To develop age-adapted prognostic tools for better sepsis management in children.

Main Methods:

  • A nested case-control study design was employed.
  • Plasma proteomes of pediatric septic patients (infants and toddlers) were analyzed.
  • Patients were compared to age-matched control groups based on clinical outcomes.

Main Results:

  • Infant sepsis showed increased protein processing (ER, proteasome, antigen processing) and decreased complement/coagulation/cholesterol metabolism compared to toddlers.
  • The pentose phosphate pathway and complement/coagulation cascades were associated with poor sepsis outcomes.
  • HP, THBS1, and SAA1/2 were identified as potential prognostic markers in infant sepsis.

Conclusions:

  • Age-specific plasma protein profiles offer insights into pediatric sepsis pathophysiology.
  • Identified biomarkers can aid in precise prognosis for pneumonia-derived sepsis in children.
  • These findings may contribute to improved survival rates in septic children through tailored treatment strategies.
Abstract

Keywords:
developmentpaediatric intensive care unitprognosisproteomicssepsis

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