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Medicinal mushrooms: Clinical perspective and challenges
Sujogya Kumar Panda1, Walter Luyten2
1Department of Biology, KU Leuven, 3000 Leuven, Belgium; Center of Environment Climate Change and Public Health, RUSA 2.0, Utkal University, Vani Vihar, Bhubaneswar 751004, Odisha, India.
Abstract:
Mushrooms are valued by humans worldwide as food, but also for their medicinal properties. Over 130 medicinal effects of mushrooms have been reported, including anti-diabetic, antioxidant, antimicrobial, anticancer, prebiotic, immunomodulating, anti-inflammatory and cardiovascular benefits. Several mushrooms have been tested in phase I, II, or III clinical trials for various diseases, including cancers, as well as to modulate immunity. Here, we review clinical studies on medicinal mushrooms or preparations (but not pure compounds) derived thereof. Overall, few phase III trials have been performed, and in many cases, these trials included a relatively small number of patients. Therefore, despite the promising published clinical data, especially on immune modulation, more work is required to clarify the therapeutic value of mushrooms.
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