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Related Concept Videos

Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Epigenetic modifications in neuropathic pain.

Danzhi Luo1,2, Xiaohong Li1, Simin Tang3

  • 1Department of Anesthesiology, The First People's Hospital of Foshan, Foshan, China.

Molecular Pain
|November 26, 2021
PubMed
Summary

Epigenetic modifications, like DNA methylation and histone changes, are key in developing neuropathic pain (NP). Emerging epigenetic therapies offer new treatment targets for this debilitating condition.

Keywords:
epigenetic modificationneuropathic paintranscription

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Neuropathic pain (NP) significantly impacts patient quality of life.
  • Epigenetics involves heritable gene expression changes without altering DNA sequence.
  • Epigenetic mechanisms mediate gene-environment interactions.

Purpose of the Study:

  • To review current knowledge on epigenetic modifications in NP development and maintenance.
  • To illustrate how epigenetic modifications regulate gene expression and crosstalk.
  • To discuss the potential of epigenetic therapies for NP.

Main Methods:

  • Literature review focusing on epigenetic mechanisms in neuropathic pain.
  • Analysis of DNA methylation, histone modification, non-coding RNA, and RNA modification roles.
  • Examination of evidence for epigenetic therapies in NP.

Main Results:

  • Epigenetic modifications are increasingly recognized in NP development.
  • Specific epigenetic mechanisms like DNA methylation and histone modification are implicated.
  • Crosstalk between epigenetic factors influences gene expression in NP.

Conclusions:

  • Epigenetic modifications play a crucial role in the pathophysiology of NP.
  • Understanding these mechanisms provides insights into NP.
  • Epigenetic therapies represent a promising avenue for novel NP treatments.