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MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

Federica Barutta1, Beatrice Corbetta2, Stefania Bellini2

  • 1Diabetic Nephropathy Laboratory, Department of Medical Sciences, University of Turin, C/so Dogliotti 14, 10126, Turin, Italy. federica.barutta@unito.it.

Journal of Translational Medicine
|November 26, 2021
PubMed
Abstract

Insights

Lower serum levels of microRNA-146a-5p (miR-146a-5p) are linked to increased risk of type 1 diabetes complications. This suggests miR-146a-5p may serve as a novel biomarker for diabetic complications, particularly cardiovascular disease and retinopathy.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • MicroRNA-146a-5p (miR-146a-5p) is a crucial regulator of inflammation.
  • Altered miR-146a-5p expression is observed in diabetic complication target organs, and its deficiency is implicated in pathogenesis.
  • This study investigates the association between serum miR-146a-5p levels and micro/macrovascular complications in type 1 diabetes (DM1).

Purpose of the Study:

  • To determine if serum miR-146a-5p levels are independently associated with micro/macrovascular complications in type 1 diabetes (DM1).

Main Methods:

  • A nested case-control study involving 447 DM1 patients from the EURODIAB PCS was conducted.
  • Serum miR-146a-5p levels were quantified using qPCR and normalized with U6 snRNA and Cel-miR-39 spike.
  • Logistic regression analysis was employed to assess the association between miR-146a-5p levels and diabetes complications.

Main Results:

  • Patients with diabetes complications (cases) exhibited significantly lower serum miR-146a-5p levels compared to controls.
  • Higher miR-146a-5p levels (upper quartile) were inversely associated with a reduced odds ratio for all diabetes complications (OR 0.34).
  • This inverse association was particularly noted for cardiovascular diseases (CVD) (OR 0.31) and diabetic retinopathy (OR 0.40), independent of other clinical factors.

Conclusions:

  • Serum miR-146a-5p is inversely and independently associated with chronic complications of type 1 diabetes, including CVD and retinopathy.
  • These findings suggest that miR-146a-5p may represent a novel candidate biomarker for predicting and monitoring diabetic complications.
Keywords:
Cardiovascular diseasesMicroRNAsRetinopathyType 1 diabetes

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