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Updated: Oct 12, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Improved water dispersion and bioavailability of coenzyme Q10 by bacterial cellulose nanofibers
Yuanyuan Li1, Qilei Yang2, Bingxue Liu2
1College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China; Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education Northeast Forestry University, Harbin 150040, Heilongjiang, China.
Abstract:
The purpose of this study was to investigate the potential of bacterial cellulose nanofiber suspension (BCNs) as stabilizer in anti-solvent precipitation and its effect on improving bioavailability of coenzyme Q10. Bacterial cellulose (BC) was hydrolyzed by sulfuric acid followed by the oxidation with hydrogen peroxide to prepare BCNs. The suspension of BCNs-loaded CoQ10 (CoQ10-BCNs) were prepared by antisolvent precipitation. The zeta potential of CoQ10-BCNs was about -36.01 mV. The properties of CoQ10, BCNs and CoQ10-BCNs were studied by scanning electron microscopy, transmission electron microscope, Fourier-transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and thermo gravimetric analysis. The crystallinity of CoQ10 decreased in CoQ10-BCNs compared with the raw CoQ10, and CoQ10-BCNs have good physicochemical stability. In oral bioavailability studies, the area under curve (AUC) of CoQ10-BCNs was about 3.62 times higher than the raw CoQ10 in rats.
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