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Updated: Jul 21, 2026
Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Effect of tranexamic acid on the prognosis of patients with traumatic brain injury undergoing craniotomy: study
1Department of Anaesthesiology, Beijing Tian Tan hospital, Capital Medical University, Beijing, China.
Introduction:
Abnormal coagulation function aggravates the prognosis of patients with traumatic brain injury (TBI). It was reported that the antifibrinolytic drug tranexamic acid (TXA) could reduce intracranial haemorrhage and mortality in non-operative patients with TBI. However, there is a lack of evaluation of TXA in patients with TBI undergoing craniotomy.
Methods And Analysis:
This is a single-centre randomised controlled, double-blind, parallel study aiming to investigate the effectiveness and safety of TXA in patients with TBI during the perioperative period. Blood loss and transfusion, neurological function, adverse events, mortality and serum immune-inflammatory cytokines will be collected and analysed.
Ethics And Dissemination:
Ethical approval has been granted by the Medical Ethics Committee of Beijing Tian Tan Hospital, Capital Medical University (reference number KY 2020-136-03). The results of this study will be disseminated through presentations at scientific conferences and publication in peer-reviewed journals.
Trial Registration Number:
ChiCTR2100041911.
