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Related Experiment Videos

The rotorfermentor. II. Application to ethanol fermentation.

A Margaritis, C R Wilke

    Biotechnology and Bioengineering
    |May 1, 1978
    PubMed
    Summary

    The rotorfermentor significantly enhances ethanol production by Saccharomyces cerevisiae, achieving 10x higher productivity than traditional methods. This advanced fermentation technology offers economic benefits, reducing capital costs and power consumption.

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    Area of Science:

    • Biotechnology
    • Chemical Engineering
    • Microbiology

    Background:

    • High cell concentration fermentation is crucial for efficient bioprocesses.
    • Traditional continuous stirred tank (CST) fermentors have limitations in productivity and efficiency.
    • The rotorfermentor offers a novel approach to high cell density fermentation.

    Purpose of the Study:

    • To evaluate the operational feasibility of the rotorfermentor for microbial growth and product formation.
    • To compare the ethanol production kinetics and productivity of the rotorfermentor with a conventional CST fermentor.
    • To assess the economic viability of the rotorfermentor for industrial-scale ethanol production.

    Main Methods:

    • Design and construction of a bench-scale pilot plant for the rotorfermentor.
    • Fermentation of glucose to ethanol using Saccharomyces cerevisiae ATCC 4126.
    • Kinetic analysis of microbial growth and ethanol production under high cell concentration conditions.

    Main Results:

    • The rotorfermentor achieved nearly 100% glucose utilization with a glucose feed concentration of 104 g/liter.
    • Ethanol productivity reached 27.3 g ethanol/liter/hr, approximately 10 times higher than that of an ordinary CST fermentor.
    • Economic analysis indicated that the rotorfermentor could replace CST fermentors and cell centrifuges, lowering capital costs and energy consumption.

    Conclusions:

    • The rotorfermentor is operationally feasible and demonstrates significantly enhanced ethanol production efficiency.
    • This technology presents a cost-effective alternative to conventional fermentation systems for industrial applications.
    • The rotorfermentor's high productivity and reduced operational costs make it a promising advancement in bioprocessing.

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