Related Experiment Video

Updated: Oct 12, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

330

Regulatory noncoding RNAs: potential biomarkers and therapeutic targets in acute myeloid leukemia

Vivek Kumar Singh1, Deepshi Thakral1, Ritu Gupta1

  • 1Laboratory Oncology, Dr B.R.A, IRCH, All India Institute of Medical Sciences New Delhi 110029, India.

American Journal of Blood Research
|November 26, 2021
PubMed

Insights

Noncoding RNAs (ncRNAs) are crucial in cell regulation and cancer. This review explores their role in acute myeloid leukemia, highlighting their potential as biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Noncoding RNAs (ncRNAs) constitute a significant portion of the human transcriptome.
  • ncRNAs play critical roles in maintaining cellular homeostasis and disease development.
  • Dysregulation of ncRNAs is implicated in various diseases, particularly cancer.

Purpose of the Study:

  • To review the role of ncRNAs in acute myeloid leukemia (AML).
  • To discuss the potential of ncRNAs as diagnostic and prognostic biomarkers in AML.
  • To explore ncRNAs as therapeutic targets for AML treatment.

Main Methods:

  • Literature review of recent research on ncRNAs in AML.
  • Analysis of ncRNA involvement in oncogenic processes relevant to AML.
  • Examination of emerging therapeutic strategies targeting ncRNAs.

Main Results:

  • ncRNAs regulate key oncogenic processes in hematopoietic cells, including differentiation, proliferation, apoptosis, migration, and angiogenesis.
  • Aberrant ncRNA expression and motif alterations are linked to cancer pathogenesis.
  • ncRNAs show promise as biomarkers for AML diagnosis and prognosis.

Conclusions:

  • ncRNAs are integral to AML development and progression.
  • Targeting ncRNAs offers a promising strategy for next-generation AML therapeutics.
  • Advances in antisense oligonucleotides and small molecule inhibitors enhance ncRNA-targeted therapy development.
Keywords:
AMLLNANoncoding RNAacute myeloid leukemiacircRNAlnc-RNAmiRNAoncomiRs

More Related Videos

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

7.7K
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

18.3K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
69.4K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.2K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
258
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.1K