Related Experiment Video

Updated: Oct 12, 2025

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
13:51

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

Published on: November 11, 2018

10.0K

Role of Rab GTPases in Hepatocellular Carcinoma

Chun-Cheng Yang1, Guang-Xiao Meng1, Zhao-Ru Dong1

  • 1Department of General Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China.

Journal of Hepatocellular Carcinoma
|November 26, 2021
PubMed

Insights

Rab GTPases regulate intracellular trafficking and are implicated in diseases like cancer. This review highlights their role in hepatocellular carcinoma (HCC) and potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Rab GTPases are key regulators of intracellular membrane trafficking.
  • Dysregulation of Rab GTPase is linked to various diseases, including cancer.
  • Rab GTPases play roles in viral replication and are implicated in hepatocarcinogenesis.

Purpose of the Study:

  • To review recent advancements on Rab GTPases in hepatocellular carcinoma (HCC).
  • To explore the role of Rab GTPase alterations in HCC progression.
  • To discuss Rab GTPases as potential therapeutic targets for HCC.

Main Methods:

  • Literature review of recent studies on Rab GTPases and HCC.
  • Analysis of the involvement of Rab GTPase expression in tumor cell proliferation, invasion, and migration.
  • Investigation of noncoding RNA regulation of Rab gene expression.

Main Results:

  • Altered Rab GTPase expression significantly impacts HCC progression.
  • Rab GTPases are involved in critical cellular processes relevant to cancer.
  • Noncoding RNAs, such as miRNAs and circRNAs, regulate Rab gene expression.

Conclusions:

  • Rab GTPases are crucial in hepatocellular carcinoma development and progression.
  • Rab GTPase dysregulation presents promising therapeutic strategies for HCC.
  • Further research into Rab GTPases and their regulatory mechanisms is warranted for effective HCC treatment.
Keywords:
Rab GTPasehepatocellular carcinomamembrane traffickingtherapeutic target

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