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Updated: Oct 12, 2025

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Fungal cell wall components modulate our immune system.

Benoit Briard1, Thierry Fontaine2, Thirumala-Devi Kanneganti3

  • 1INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Université de Tours, Faculté de Médecine de Tours, Tours, France.

Cell Surface (Amsterdam, Netherlands)
|November 26, 2021
PubMed
Summary

Invasive fungal infections cause over 1 million deaths annually. Understanding how fungal cell wall components interact with the immune system offers new strategies to combat these deadly diseases.

Keywords:
Cell deathCell wallImmunometabolismInflammasomeInnate immunityMelaninPANoptosisPolysaccharidesPyroptosisTrained immunity

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Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Invasive fungal infections pose a significant global health burden, causing over 1 million deaths yearly.
  • Understanding fungal pathobiology and host immune interactions is crucial for developing effective treatments.

Purpose of the Study:

  • To highlight advancements in understanding fungal cell wall components and their role in modulating host immunity.
  • To explore new immunomodulatory strategies for combating invasive fungal infections.

Main Methods:

  • Review of current research on fungal cell wall components (β-glucan, mannan, galactosaminogalactan, melanin).
  • Analysis of their impact on host immune responses.
  • Discussion of potential therapeutic applications.

Main Results:

  • Fungal cell wall components critically influence host immune responses.
  • Specific components like β-glucan, mannan, galactosaminogalactan, and melanin play pivotal roles.
  • These interactions present novel targets for immunomodulation.

Conclusions:

  • Targeting fungal cell wall-immune system interactions can lead to innovative therapies.
  • Further research into these components can combat deadly fungal infectious diseases.
  • Developing immunomodulatory strategies is key to reducing mortality and morbidity from fungal infections.