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The emerging roles of srGAPs in cancer

Vaishali Ji1, Chandra Kishore2

  • 1Department of Botany, Patna Science College, Patna, 800005, India.

Molecular Biology Reports
|November 26, 2021
PubMed

Insights

GTPase activating proteins (GAPs) initially viewed as inhibitors, are now recognized for their crucial roles in cancer development. Recent research highlights their diverse functions in various cancers, particularly srGAPs.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • GTPase activating proteins (GAPs) were traditionally considered inhibitors of cell signaling by activating RhoGTPase activity.
  • Dysregulation of GAPs is increasingly implicated in the development of various cancers, including glioblastoma, colorectal, breast, and renal cancers.

Purpose of the Study:

  • To review recent advancements in understanding the roles of GAPs, specifically SLIT-ROBO Rho GTPase-activating proteins (srGAPs), in cancer.
  • To highlight the non-conventional functions of GAPs in different cellular contexts relevant to carcinogenesis.

Main Methods:

  • Literature review of recent studies on GAPs and srGAPs in cancer.
  • Analysis of the dual role of GAPs in cell signaling and cancer development.

Main Results:

  • GAPs exhibit multifaceted roles beyond simple inhibition, actively participating in carcinogenesis.
  • Specific srGAP family members display significant involvement in the progression of multiple cancer types.

Conclusions:

  • GAPs are critical players in cancer, with functions extending beyond their canonical roles.
  • Further investigation into srGAPs is essential for understanding their therapeutic potential in oncology.
Keywords:
CancerGAPsRho-GDPRho-GTPRhoGTPasessrGAPs

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