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Updated: Oct 12, 2025

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Emerging Theranostic Nanomaterials in Diabetes and Its Complications
Yuntao Liu1,2, Siqi Zeng2, Wei Ji3
1School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212013, China.
Abstract:
Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long-term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia-induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.
Insights
Nanomaterials offer new solutions for diabetes mellitus (DM) detection and treatment, addressing limitations of traditional drugs and preventing complications. This review explores their potential in diagnostics and therapeutics for better diabetes management.
Area of Science:
- Biomedical Engineering
- Materials Science
- Endocrinology
Background:
- Diabetes mellitus (DM) is a group of metabolic disorders marked by hyperglycemia.
- Conventional antidiabetic drugs like insulin, glipalamide, and metformin have side effects and limited long-term efficacy.
- Diabetics face increased risks of complications due to oxidative stress and vascular damage.
Purpose of the Study:
- To provide a comprehensive overview of nanomaterials for diabetes diagnosis and treatment.
- To elucidate the application of nanomaterials in preventing diabetic complications.
- To discuss current challenges and future trends in nanomedicine for diabetes.
Main Methods:
- Review of current literature on nanomaterials used in diabetes detection.
- Analysis of nanomaterial-based therapeutic strategies for diabetes.
- Examination of bioengineered nanoparticles for managing diabetic complications.
Main Results:
- Nanomaterials show promise for sensitive detection of diabetic biomarkers.
- Engineered nanoparticles offer novel therapeutic approaches for blood glucose control.
- Nanomaterials can mitigate various diabetes-related complications.
Conclusions:
- Nanomaterials represent a significant advancement in diabetes mellitus management.
- Further research into novel nanomaterials is crucial for improved diagnostics and therapeutics.
- The field is rapidly evolving, with potential for personalized diabetes care.
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