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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Acute pancreatitis caused by methimazole/carbimazole assumption: a case-series

Andrea Sarro1, Riccardo Esposito2, Angelica Zibetti3

  • 1Department of Translational Medicine (DIMET), University of Eastern Piedmont, Novara, Italy - andrea.sarro@uniupo.it.

Minerva Endocrinology
|November 26, 2021
PubMed

Insights

Methimazole (MMI) and its prodrug carbimazole (CBZ) may be associated with acute pancreatitis. A review of 7 case reports suggests a potential link, but more research is needed to confirm this drug-induced condition.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Pharmacology

Background:

  • The World Health Organization (WHO) identifies numerous drugs as potential causes of acute pancreatitis.
  • Methimazole (MMI), also known as thiamazole, and its prodrug carbimazole (CBZ) are used to treat hyperthyroidism.
  • MMI/CBZ are listed by the WHO as drugs that can cause acute pancreatitis.

Purpose of the Study:

  • To investigate the potential association between methimazole (MMI) or carbimazole (CBZ) and acute pancreatitis.
  • To systematically review existing case reports linking MMI/CBZ exposure to acute pancreatitis.

Main Methods:

  • A systematic literature search was conducted on MEDLINE (PubMed).
  • Case reports of patients experiencing acute pancreatitis following MMI or CBZ exposure were included.
  • Data extraction and analysis were performed in duplicate.

Main Results:

  • Seven case reports were identified, predominantly involving female patients.
  • The average age of affected patients ranged from 18 to 80 years.
  • Acute pancreatitis symptoms typically emerged 2-3 weeks after initiating MMI/CBZ therapy.

Conclusions:

  • A potential association exists between MMI/CBZ exposure and acute pancreatitis.
  • The current evidence is limited and derived from case reports.
  • Further high-quality studies are required to confirm the causal relationship between MMI/CBZ and drug-induced pancreatitis.

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