Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
1Scientist Emeritus, Mouse Cancer Genetics Program, CCR, NCI at Frederick, National Institutes of Health, Frederick, MD, 21702, USA.
Abstract:
In the 35 years since the introduction of the "proline cycle", its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases. In addition, the multi-layered connections of the proline cycle and the role of proline and hydroxyproline in collagen provide an important regulatory link between the extracellular matrix and metabolism.
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