Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis
1Scientist Emeritus, Mouse Cancer Genetics Program, CCR, NCI at Frederick, National Institutes of Health, Frederick, MD, 21702, USA.
Amino Acids
|November 26, 2021
Summary
The proline cycle is crucial in human tumors, influencing cancer and metastasis. Targeting this cycle with small molecule inhibitors offers a promising therapeutic strategy for cancer treatment.
Area of Science:
- Biochemistry
- Oncology
- Metabolic pathways
Background:
- The proline cycle's role in human tumors has been recognized for 35 years.
- Numerous mechanisms link the proline cycle to cancer development and progression.
- Proline and hydroxyproline are key components of collagen, connecting extracellular matrix and metabolism.
Purpose of the Study:
- To review the established relevance of the proline cycle in human tumors.
- To highlight the potential of targeting the proline cycle for cancer therapy.
- To emphasize the regulatory link between the proline cycle, collagen, and cellular metabolism.
Main Methods:
- Literature review of studies on the proline cycle in cancer.
- Analysis of mechanisms connecting the proline cycle to tumor growth and metastasis.
- Examination of the role of proline and hydroxyproline in collagen synthesis and its metabolic implications.
Main Results:
- The proline cycle is implicated in various human tumors through diverse mechanisms.
- Small molecule inhibitors targeting the proline cycle are being developed for cancer treatment.
- The proline cycle regulates the interplay between the extracellular matrix and cellular metabolism via collagen.
Conclusions:
- The proline cycle is a validated target for anti-cancer drug development.
- Understanding the proline cycle's multifaceted roles is essential for advancing cancer therapy.
- Targeting the proline cycle offers a strategy to disrupt tumor growth and metastasis by modulating metabolic and extracellular matrix interactions.
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