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Updated: Oct 12, 2025

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
Published on: March 2, 2016
Heat Stress-Mediated Activation of Immune-Inflammatory Pathways
Juan M Cantet1, Zhantao Yu1, Agustín G Ríus1
1Department of Animal Science, The University of Tennessee Institute of Agriculture (UTIA), Knoxville, TN 37996, USA.
Abstract:
Physiological changes in animals exposed to elevated ambient temperature are characterized by the redistribution of blood toward the periphery to dissipate heat, with a consequent decline in blood flow and oxygen and nutrient supply to splanchnic tissues. Metabolic adaptations and gut dysfunction lead to oxidative stress, translocation of lumen contents, and release of proinflammatory mediators, activating a systemic inflammatory response. This review discusses the activation and development of the inflammatory response in heat-stressed models.
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