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Global Spread and Molecular Characterization of CTX-M-Producing Salmonella Typhimurium Isolates

Lili Guo1,2, Yongda Zhao1

  • 1Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266000, China.

Antibiotics (Basel, Switzerland)
|November 27, 2021
PubMed

Insights

CTX-M-producing Salmonella Typhimurium are globally prevalent, particularly in China, and carry numerous antibiotic resistance and virulence genes. Continued surveillance in humans and animals is crucial to monitor these resistant bacteria.

Area of Science:

  • Microbiology
  • Genomics
  • Public Health

Background:

  • CTX-M-producing Salmonella Typhimurium poses a significant global health threat.
  • Understanding the prevalence and characteristics of these resistant strains is essential for effective control strategies.

Purpose of the Study:

  • To determine the global prevalence and molecular characteristics of CTX-M-producing Salmonella Typhimurium.
  • To identify key sequence types, plasmid types, and co-existing antimicrobial resistance genes (ARGs) and virulence genes.

Main Methods:

  • Systematic literature review of public databases for blaCTX-M-positive S. Typhimurium isolates.
  • Whole Genome Sequencing (WGS) analysis for molecular characterization, including sequence types (STs) and plasmid analysis.
  • Identification and quantification of ARGs and virulence genes.

Main Results:

  • 330 blaCTX-M-positive S. Typhimurium isolates were identified, with blaCTX-M-9 being the most prevalent variant.
  • Isolates originated primarily from humans and animals, with significant detection in China, the UK, Australia, USA, and Germany.
  • Dominant sequence types were ST34, ST19, and ST313; IncI and IncHI2 plasmids carried blaCTX-M.
  • Isolates harbored multiple ARGs conferring resistance to five antimicrobial classes and numerous virulence genes.

Conclusions:

  • China shows severe contamination with blaCTX-M-positive S. Typhimurium.
  • These isolates possess a high burden of ARGs and virulence genes, increasing their public health impact.
  • Urgent and continued vigilance for these resistant strains in both animal and human populations is necessary.
Keywords:
ARGsCTX-MMLSTSalmonella Typhimuriumglobal distribution

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