Related Experiment Video
Updated: Oct 12, 2025
23:56
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
16.9K
Is Aducanumab for LMICs? Promises and Challenges
Illangage P C Gunawardena1, Thaarvena Retinasamy2, Mohd Farooq Shaikh2
1Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Johor Bahru 80100, Johor, Malaysia.
Brain Sciences
|November 27, 2021
Summary
Aducanumab, a new Alzheimer's treatment, faces scrutiny regarding its effectiveness and cost in low-income nations. This analysis explores its suitability and economic viability for global accessibility.
Area of Science:
- Neurology
- Pharmacology
- Global Health
Background:
- Aducanumab is the first disease-modifying therapy for Alzheimer's disease approved by the U.S. FDA.
- Alzheimer's disease significantly impacts patients, caregivers, and economies, particularly in low- and middle-income countries (LMICs).
Purpose of the Study:
- To evaluate the role, appropriateness, and cost-effectiveness of aducanumab in LMICs.
- To examine controversies surrounding aducanumab, including trial data and resource requirements for safe and effective delivery.
Main Methods:
- Review of clinical trial data (EMERGE and ENGAGE) for aducanumab efficacy.
- Analysis of logistical and economic factors pertinent to aducanumab implementation in LMICs.
Main Results:
- Contradictory evidence exists between the EMERGE and ENGAGE trials regarding aducanumab's efficacy.
- Significant resource allocation is necessary for the safe and effective administration of aducanumab.
Conclusions:
- Aducanumab's broad applicability in LMICs is questionable due to efficacy concerns and high implementation costs.
- Further research is needed to determine aducanumab's true value and accessibility for diverse global populations.
Related Concept Videos
01:26Methods Of Healthcare Delivery System
3.6K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.6K
01:28Drug Products: Biologics, Biosimilars and Interchangeables
12
Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
12
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.0K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.0K
01:25Immunodeficiency Diseases
1.3K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.3K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
259
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
259
01:30Cancer Vaccines
558
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
558