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The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
1Area of Biochemistry and Molecular Biology, Department of Basic Sciences of Health, Faculty of Sciences of Health, Campus of Alcorcón, University Rey Juan Carlos, 28922 Madrid, Spain.
Biomolecules
|November 27, 2021
Summary
The parathyroid hormone-related protein (PTHrP)/Parathyroid Hormone Receptor 1 (PTH1R) axis plays a key role in regulating adipose tissue. PTHrP shows potential for treating obesity and related metabolic disorders.
Area of Science:
- Endocrinology
- Metabolic Science
- Adipose Tissue Biology
Background:
- Adipose tissue is a plastic organ crucial for energy homeostasis and endocrine regulation.
- The parathyroid hormone-related protein (PTHrP)/Parathyroid Hormone Receptor 1 (PTH1R) axis influences adipogenesis, counteracting Peroxisome proliferator-activated receptor gamma (PPARγ).
- PTHrP is upregulated in adipose tissue during physiological stress, promoting browning and lipolysis, but also in obesity and related metabolic diseases.
Purpose of the Study:
- To elucidate the role of the PTHrP/PTH1R axis in adipose tissue differentiation and remodeling.
- To explore the therapeutic potential of PTHrP in managing obesity and its associated metabolic complications.
- To investigate PTHrP as a potential biomarker for placental health and maternal metabolic adaptations.
Main Methods:
- Review of recent studies on the PTHrP/PTH1R axis in adipose tissue.
- Analysis of PTHrP expression patterns in various physiological and pathological conditions.
- Evaluation of the functional impact of PTHrP on adipogenesis, adipose tissue expansion, and insulin sensitivity.
Main Results:
- The PTHrP/PTH1R axis is integral to adipose tissue differentiation and remodeling.
- PTHrP overexpression in adipose tissue can promote browning and lipolysis.
- Dysregulated PTHrP expression is observed in obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM).
Conclusions:
- The PTHrP/PTH1R axis is a significant regulator of adipose tissue.
- PTHrP holds promise for obesity treatment by reprogramming adipogenesis, promoting WAT browning, and enhancing insulin sensitivity.
- PTHrP may serve as a biomarker for placental status and maternal adaptations, aiding in the prevention of metabolic issues in mothers and children, and in treating bone diseases like osteoporosis.
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