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Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
Chia-Chen Hsieh1,2, Ming-Jen Chan1,2, Yi-Jiun Su3
1Clinical Poison Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou 333, Taiwan.
Healthcare (Basel, Switzerland)
|November 27, 2021
Summary
Bone marrow hypocellularity is common in patients with kidney dysfunction, occurring more frequently in end-stage kidney disease (ESKD) than chronic kidney disease (CKD). This highlights the need for further research into bone marrow pathology in these patient groups.
Area of Science:
- Nephrology
- Hematology
- Pathology
Background:
- Anemia and pancytopenia are frequent in chronic kidney disease (CKD) patients.
- Limited research exists on bone marrow pathology in CKD or end-stage kidney disease (ESKD) patients on dialysis.
Purpose of the Study:
- To analyze bone marrow pathology in patients with CKD and ESKD.
- To compare bone marrow findings between CKD and ESKD patients.
Main Methods:
- Observational cohort study including 22 ESKD and 23 CKD patients.
- Bone marrow biopsy and aspiration performed.
- Demographic, hematological, and biochemical data collected for analysis.
Main Results:
- ESKD patients had a lower percentage of bone marrow blasts compared to CKD patients (0.52% vs 1.06%, p=0.033).
- Overall hypocellular bone marrow incidence was 55.6%.
- ESKD patients showed a higher proportion of hypocellular bone marrow than CKD patients (72.7% vs 39.1%, p=0.023).
- ESKD status (OR 9.43) and megakaryocyte count (OR 0.48) were significant predictors of hypocellularity.
Conclusions:
- Bone marrow hypocellularity is prevalent in patients with kidney dysfunction.
- Hypocellular bone marrow is more common in ESKD patients compared to CKD patients.
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