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Related Experiment Video

Updated: Oct 12, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Intracranial Involvement in Takayasu's Arteritis.

Andrea Johnson1, Derek Emery2, Alison Clifford1

  • 1Division of Rheumatology, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Diagnostics (Basel, Switzerland)
|November 27, 2021
PubMed
Summary

Takayasu

Area of Science:

  • Neurology
  • Rheumatology
  • Vascular Medicine

Background:

  • Takayasu's arteritis (TAK) is a large-vessel vasculitis affecting the aorta and its branches.
  • Extracranial vascular involvement is common, but intracranial involvement is less understood.

Purpose of the Study:

  • To determine the prevalence of intracranial vascular involvement in patients with Takayasu's arteritis.
  • To describe intracranial vascular and non-vascular findings in TAK patients.

Main Methods:

  • Retrospective review of clinical and imaging records of TAK patients at a Canadian university medical center.
  • Analysis of neuroimaging (CTA, MRA, angiography) for intracranial vascular lesions.
  • Literature review on intracranial involvement in TAK.
Keywords:
Takayasu’s arteritisimagingintracranialstrokevasculitis

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Main Results:

  • Of 20 TAK patients, 12 underwent vascular neuroimaging.
  • Intracranial vascular lesions were found in 4 patients (33.3% of those imaged, 20% of all patients).
  • Findings suggest a higher prevalence of intracranial involvement than previously recognized.

Conclusions:

  • Intracranial vascular involvement in Takayasu's arteritis may be more frequent than commonly believed.
  • Consideration of both intracranial and extracranial vessel imaging is recommended for young TAK patients.