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Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

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Published on: October 19, 2013

Oxidative Stress in Preterm Newborns.

Chiara Lembo¹, Giuseppe Buonocore¹, Serafina Perrone²

¹Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.

Antioxidants (Basel, Switzerland)

|November 27, 2021

Summary

Preterm infants face high oxidative stress (OS) risks, leading to serious health issues. This review explores OS biomarkers for early diagnosis and new antioxidant therapies to prevent and treat these conditions.

Keywords:

antioxidants biomarkers free radicals newborn infants oxidative stress prematurity

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Area of Science:

Neonatal Medicine
Biochemistry
Pediatric Pathology

Background:

Preterm infants exhibit an imbalance in oxidant and antioxidant systems, increasing susceptibility to oxidative stress (OS).
Free radical (FR) generation causes significant oxidative damage to multiple organs and systems in newborns.
OS is a primary factor in typical premature infant diseases like bronchopulmonary dysplasia, retinopathy of prematurity, and necrotizing enterocolitis.

Purpose of the Study:

To review current knowledge on oxidative stress in preterm newborns.
To highlight new findings on OS biomarkers for early diagnosis.
To discuss the implementation of antioxidant strategies for disease prevention and treatment.

Main Methods:

Literature review of scientific articles and clinical studies.
Analysis of current research on oxidative stress biomarkers in neonates.
Synthesis of data on antioxidant therapeutic approaches for preterm infants.

Main Results:

Oxidative stress is implicated in numerous severe conditions affecting preterm infants.
Various biomarkers are identified for early detection of free radical-mediated diseases.
Emerging antioxidant strategies show promise for managing these conditions.

Conclusions:

Oxidative stress poses a significant threat to preterm infant health, contributing to major morbidities.
OS biomarkers are crucial for early identification of at-risk newborns.
Targeted antioxidant therapies are essential for preventing and treating diseases and sequelae in preterm infants.