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Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

Eleftheria Lakiotaki1, Dimitrios S Kanakoglou1, Andromachi Pampalou1

  • 1First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece.

Biomedicines
|November 27, 2021
PubMed

Insights

Circular RNAs (circRNAs) regulate cancer progression and chemoresistance. This review focuses on circRNAs in osteosarcoma and other sarcomas, highlighting their potential as diagnostic and therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are unique RNA molecules formed by back-splicing.
  • They regulate gene expression through various mechanisms, including miRNA sponging and protein interactions.
  • Sarcomas are rare mesenchymal tumors often diagnosed at advanced stages.

Purpose of the Study:

  • To review the regulatory roles of circRNAs in osteosarcoma progression.
  • To explore the oncogenic functions of circRNAs in other mesenchymal tumors.
  • To discuss the potential of circRNAs as biomarkers and therapeutic targets in sarcomas.

Main Methods:

  • Literature review of studies on circRNAs in sarcoma.
  • Analysis of circRNA regulatory mechanisms in tumorigenesis.
  • Examination of diagnostic, prognostic, and therapeutic applications.

Main Results:

  • CircRNAs play significant roles in osteosarcoma progression, metastasis, and chemoresistance.
  • Oncogenic roles of circRNAs are identified in Kaposi Sarcoma, Rhabdomyosarcoma, and Gastrointestinal Stromal Tumors.
  • CircRNAs offer potential as novel biomarkers and therapeutic strategies for sarcomas.

Conclusions:

  • CircRNAs are crucial regulators in sarcoma development and progression.
  • Emerging research highlights circRNAs as promising diagnostic, prognostic, and therapeutic targets in sarcoma treatment.
  • Further investigation into circRNAs is warranted to fully exploit their clinical potential in oncology.
Keywords:
Kaposi sarcomacircular RNAsdiagnosisgastrointestinal stromal tumorsosteosarcomarhabdomyosarcomatherapy

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