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Acne Syndromes and Mosaicism.

Sumer Baroud1,2, Jim Wu1, Christos C Zouboulis1

  • 1Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, 06847 Dessau, Germany.

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Summary

Mosaicism, the presence of multiple cell genotypes, can manifest as acneiform lesions. This review explores cutaneous mosaicism and its connection to various acne syndromes and genetic mutations.

Keywords:
acnealopeciaautoinflammationendocrinologyhirsutismhormonesimmunologymosaicismpilosebaceous unitsyndromes

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Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Abnormal mosaicism involves multiple cell genotypes originating from a single zygote, potentially causing disease.
  • Acne is a chronic pilosebaceous unit inflammatory condition influenced by hormones and inflammatory signals.
  • Acneiform lesions are characteristic of several systemic and autoinflammatory syndromes.

Purpose of the Study:

  • To review the concept of cutaneous mosaicism.
  • To elaborate on acne syndromes associated with mosaicism.
  • To discuss acneiform mosaicism.

Main Methods:

  • Literature review of cutaneous mosaicism.
  • Analysis of acne syndromes and their relation to mosaicism.
  • Examination of genetic mutations linked to acneiform lesions.

Main Results:

  • Mosaicism can present with acneiform lesions.
  • Specific genetic mutations (e.g., FGFR2) are linked to acneiform conditions.
  • Various autoinflammatory syndromes feature acneiform manifestations.

Conclusions:

  • Cutaneous mosaicism is a relevant concept in understanding certain acne presentations.
  • Further research into acneiform mosaicism can elucidate disease mechanisms and treatment.