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Related Experiment Video

Updated: Oct 12, 2025

Preparation of Single-cohort Colonies and Hormone Treatment of Worker Honeybees to Analyze Physiology Associated with Role and/or Endocrine System

Preparation of Single-cohort Colonies and Hormone Treatment of Worker Honeybees to Analyze Physiology Associated with Role and/or Endocrine System

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Enterococcus faecium Regulates Honey Bee Developmental Genes.

Yating Du^1,2, Shiqi Luo², Xin Zhou²

¹College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

International Journal of Molecular Sciences

|November 27, 2021

Summary

Enterococcus faecium, a probiotic for honey bees, increases gut weight by up-regulating developmental genes. MicroRNAs (miRNAs) mediate these host-bacterial interactions at the post-transcriptional level.

Keywords:

Enterococcus faecium gut bacteria honey bee miRNA transcriptome

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Area of Science:

Microbiology
Animal Science
Genomics

Background:

Honey bees are vital pollinators, and Enterococcus faecium is used as a probiotic.
The mechanisms and safety of E. faecium in honey bees are not fully understood.

Purpose of the Study:

To sequence the E. faecium genome from honey bee guts.
To investigate the effects and mechanisms of E. faecium-honey bee interactions using transcriptomic and miRNA analysis.

Main Methods:

Nanopore sequencing for genome assembly.
Transcriptome and miRNA sequencing to analyze gene expression and regulation.
Bioinformatic analysis of host-bacterial interactions.

Main Results:

Complete genome sequence of E. faecium from honey bee gut.
E. faecium colonization significantly increased honey bee gut weight.
Upregulation of developmental genes and enrichment of miRNA target genes in developmental pathways.

Conclusions:

E. faecium enhances honey bee gut weight via transcriptional and post-transcriptional regulation.
MicroRNAs play a crucial role in mediating host-bacterial interactions in honey bees.