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BP180/Collagen XVII: A Molecular View.

Jussi Tuusa1, Nina Kokkonen1, Kaisa Tasanen1

  • 1PEDEGO Research Unit, Department of Dermatology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 8000, FI-90014 Oulu, Finland.

International Journal of Molecular Sciences
|November 27, 2021
PubMed
Summary

Bullous pemphigoid antigen 180 (BP180) is key in skin adhesion and blistering diseases. This review explores BP180

Keywords:
autoimmune diseasebullous pemphigoidhemidesmosomeintrinsically disorderedkeratinocyteprotein–protein interactiontransmembrane collagen

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Area of Science:

  • Biochemistry
  • Dermatology
  • Molecular Biology

Background:

  • BP180 is a type II transmembrane protein, crucial for hemidesmosome structure and epidermal adhesion.
  • It is the primary autoantigen in bullous pemphigoid (BP), a blistering skin disease.
  • BP180's functions beyond hemidesmosomes and its role in non-HD locations are not well understood.

Purpose of the Study:

  • To comprehensively review the properties of the BP180 molecule.
  • To present new data on the biochemical features of BP180's intracellular domain.
  • To discuss the significance of these features for BP180 folding and protein interactions.

Main Methods:

  • Literature review of BP180 properties and functions.
  • Biochemical analysis of the intracellular domain of BP180.
  • Discussion of implications for protein folding and interactions.

Main Results:

  • BP180 is a central component of hemidesmosomes, essential for skin integrity.
  • Recent research highlights novel roles in cell proliferation, differentiation, and aging.
  • New data provides insights into the biochemical characteristics of BP180's intracellular domain.

Conclusions:

  • Understanding BP180's diverse functions requires a focus on the molecule itself.
  • The biochemical features of the intracellular domain are significant for BP180's structure and interactions.
  • Further research into BP180's properties can elucidate its roles in both health and disease.