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Updated: Oct 12, 2025

Cell Population Analyses During Skin Carcinogenesis
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Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

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STING Signaling and Skin Cancers

Sayaka Sato1, Yu Sawada1, Motonobu Nakamura1

  • 1Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-Ku, Kitakyushu 807-8555, Japan.

Cancers
|November 27, 2021
PubMed

Recent developments in immunotherapy against malignancies overcome the disadvantages of traditional systemic treatments; however, this immune checkpoint treatment is not perfect and cannot obtain a satisfactory clinical outcome in all cases. Therefore, an additional therapeutic option for malignancy is needed in oncology. Stimulator of interferon genes (STING) has recently been highlighted as a strong type I interferon driver and shows anti-tumor immunity against various malignancies. STING-targeted anti-tumor immunotherapy is expected to enhance the anti-tumor effects and clinical outcomes of immunotherapy against malignancies. In this review, we focus on recent advancements in the knowledge gained from research on STING signaling in skin cancers. In addition to the limitations of STING-targeted immunotherapy, we also discuss the clinical application of STING agonists in the treatment of skin cancer.

Keywords:
IFNSTINGepigeneticsskin cancers

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