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Updated: Oct 12, 2025
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
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Epidemiology of Kaposi's Sarcoma
Sophie Grabar1, Dominique Costagliola2
1Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP) and Assistance Publique-Hôpitaux de Paris (AP-HP), Unit of Public Health, St Antoine Hospital, 75001 Paris, France.
Cancers
|November 27, 2021
Summary
Kaposi's sarcoma (KS) incidence decreased in patients with HIV due to antiretroviral therapy. However, KS remains a significant cancer risk for people living with HIV (PLHIV), especially in certain populations and regions.
Area of Science:
- Oncology
- Virology
- Epidemiology
Background:
- Kaposi's sarcoma (KS) is an angioproliferative tumor linked to human herpesvirus 8 (HHV-8) and immunodeficiency.
- Antiretroviral therapy has significantly reduced KS incidence in people living with HIV (PLHIV) by restoring immunity.
- Despite treatment advances, KS remains a prevalent cancer among PLHIV, particularly in specific demographics and endemic regions.
Purpose of the Study:
- To review the current epidemiological landscape of Kaposi's sarcoma in the context of HIV infection.
- To highlight the persistent risk of KS in PLHIV even with improved immune function.
- To emphasize the importance of early access to care alongside antiretroviral treatment for KS risk reduction.
Main Methods:
- This review synthesizes recent epidemiological data on Kaposi's sarcoma.
- It analyzes trends in KS incidence among people living with HIV (PLHIV).
- The review considers the impact of antiretroviral therapy and immune status on KS development.
Main Results:
- Antiretroviral combinations have led to a dramatic decrease in KS incidence among PLHIV.
- KS continues to be a frequent cancer in PLHIV, with higher prevalence in men who have sex with men and sub-Saharan Africa.
- The risk of KS remains over 30 times higher in PLHIV compared to the general population, even with restored immunity.
Conclusions:
- Early initiation of antiretroviral treatment is crucial for reducing KS risk in PLHIV.
- Early access to healthcare services is essential to complement antiretroviral therapy.
- Ongoing surveillance and targeted interventions are necessary to further mitigate KS burden in PLHIV.
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