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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
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Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
Gábor Cserni1,2, Cecily M Quinn3,4, Maria Pia Foschini5
1Department of Pathology, University of Szeged, 6725 Szeged, Hungary.
Cancers
|November 27, 2021
Summary
Certain triple-negative breast cancers (TNBC) exhibit indolent behavior and may not benefit from chemotherapy. This review highlights rare TNBC subtypes with better prognoses, guiding specialized treatment approaches.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Triple-negative breast cancer (TNBC) generally has a poor prognosis and lacks targeted therapies.
- TNBC is a heterogeneous group, with some rare subtypes exhibiting indolent behavior.
Purpose of the Study:
- To review literature on special histological types of breast cancer (BC) with a triple-negative phenotype and indolent clinical course.
- To summarize pathological, molecular, and clinical data for these rare TNBC subtypes.
Main Methods:
- Literature review focusing on special histological types of BC with triple-negative and indolent features.
- Synthesis of data on pathology, molecular characteristics, clinical presentation, treatment, and prognosis.
Main Results:
- Identified indolent triple-negative breast cancer subtypes include adenoid cystic carcinoma, low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade mucoepidermoid carcinoma, secretory carcinoma, acinic cell carcinoma, and tall cell carcinoma with reversed polarity.
- These rare subtypes often have distinct pathological and molecular features compared to common TNBC.
Conclusions:
- Many patients with these rare, pure TNBC subtypes may not benefit from conventional systemic chemotherapy.
- A multidisciplinary approach is recommended for the diagnosis and management of these rare tumor types.
