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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Oct 12, 2025

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes.

Emma H Allott1,2, Kellie Dean3, Tracy Robson4

  • 1Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7AE, UK.

Cancers
|November 27, 2021
PubMed
Summary

Cancer research advances highlight the tumor microenvironment

Keywords:
genetically engineered mouse modelsimmune systemmicrobiomemicroenvironmentorganoidspreclinical models

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Area of Science:

  • Cancer Research
  • Tumor Microenvironment
  • Oncology

Background:

  • The tumor microenvironment significantly influences cancer initiation, progression, and treatment response.
  • Understanding the complex interplay of cellular and non-cellular components is crucial for effective cancer therapies.

Framework:

  • The 57th Irish Association for Cancer Research (IACR) Annual Conference convened experts to discuss microenvironment's role and treatment advances.
  • Key microenvironment factors include the microbiome, metabolism, and immune response.

Implementation:

  • The article reviews progress in preclinical models that better simulate complex tumor microenvironments.
  • It also addresses the integration of psycho-social oncology perspectives.

Implications:

  • Advances in understanding the tumor microenvironment are paving the way for novel cancer treatment strategies.
  • Shared decision-making in cancer care is emphasized in light of emerging therapies.