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Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy

Minsu Kim1, Seok Chan Park1, Dong Yun Lee1,2,3

  • 1Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Korea.

Cancers
|November 27, 2021
PubMed

Insights

Glycyrrhizin (GL) may overcome multidrug resistance (MDR) in cancer chemotherapy by regulating nitric oxide (NO) and inhibiting ATP-dependent pumps, enhancing treatment efficacy.

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Multidrug resistance (MDR) significantly limits chemotherapy effectiveness in cancer treatment.
  • ATP-dependent drug efflux is a primary mechanism driving MDR.
  • Nitric oxide (NO) has shown potential in overcoming MDR by inhibiting ATPase pumps.

Purpose of the Study:

  • To explore the potential of Glycyrrhizin (GL) as a nitric oxide (NO) regulator and MDR inhibitor.
  • To assess GL's efficacy in reducing MDR in the tumor microenvironment (TME).

Main Methods:

  • Review of existing literature on Glycyrrhizin (GL), nitric oxide (NO), and multidrug resistance (MDR).
  • Analysis of GL's reported mechanisms, including ATP-dependent pump inhibition and NO modulation.

Main Results:

  • Glycyrrhizin (GL) demonstrates dual action: inhibiting ATP-dependent pumps and regulating NO production.
  • GL shows promise in overcoming MDR by targeting key mechanisms within the TME.

Conclusions:

  • Glycyrrhizin (GL) presents a promising therapeutic strategy to enhance cancer chemotherapy by combating MDR.
  • Targeting NO production and ATPase activity with GL could improve patient outcomes in chemotherapy.
Keywords:
ATP-biding cassettechemotherapyglycyrrhizinmultidrug resistancenitric oxidetumor microenvironment

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