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Neurogenesis and Regeneration of Nervous Tissue

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Related Experiment Video

Updated: Oct 12, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Cell-to-Cell Interactions Mediating Functional Recovery after Stroke.

Claudia Alia¹, Daniele Cangi², Verediana Massa¹

¹Neuroscience Institute, National Research Council (CNR), Via G. Moruzzi 1, 56124 Pisa, Italy.

|November 27, 2021

Summary

Altered cell-to-cell interactions after brain ischemia can hinder or aid stroke recovery. Targeting these interactions offers promising therapeutic strategies for neurorehabilitation.

Keywords:

astrocytes interneurons microglia oligodendrocytes stroke

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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

Area of Science:

Neuroscience
Cell Biology
Neurorehabilitation

Background:

Ischemic brain damage induces significant molecular and structural changes affecting cell communication.
Understanding these intercellular interactions is crucial for effective post-stroke recovery.

Purpose of the Study:

To review literature on post-stroke alterations in cell-to-cell interactions.
To explore how these changes impact functional recovery, considering both detrimental and supportive roles.
To discuss therapeutic strategies targeting these interactions for clinical application.

Main Methods:

Literature review of studies on post-stroke cellular interactions.
Analysis of roles of astrocytes, oligodendrocytes, microglia, and neurons (pyramidal and GABAergic).
Examination of spontaneous changes and experimental interventions.

Main Results:

Post-stroke changes in astrocytes (reactive astrogliosis), oligodendrocytes (neuronal support, sprouting inhibition), and microglia (neuroinflammation) are discussed.
Alterations in interactions involving pyramidal and GABAergic neurons are described.
Both spontaneous and targeted modifications of cellular interactions are evaluated for their impact on recovery.

Conclusions:

Cell-to-cell interactions are critical targets for neurorehabilitation strategies after stroke.
Manipulating these interactions, considering their complex roles, holds therapeutic potential for improving functional outcomes.