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Updated: Oct 12, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
Peter J Kennel1, P Christian Schulze1
1Department of Medicine I, Division of Cardiology, University Hospital Jena, Friedrich-Schiller-University Jena, Am Klinikum 1, 07747 Jena, Germany.
Abstract:
MiRNA-regulated processes are pivotal in cardiovascular homeostasis and disease. These short non-coding RNAs have ideal properties that could be utilized as potential biomarkers; moreover, their functions as post-transcriptional regulators of mRNA make them interesting therapeutic targets. In this review, we summarize the current state of miRNA-based biomarkers in a variety of diseases leading to heart failure, as well as provide an outlook on developing miRNA-based therapies in the heart failure field.
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