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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Updated: Oct 12, 2025

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ROS-Based Nanoparticles for Atherosclerosis Treatment.

Xin Hu1, Pengxuan Zhao1, Yongping Lu2

  • 1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Materials (Basel, Switzerland)
|November 27, 2021
PubMed
Summary

Reactive oxygen species (ROS)-based nanoparticles offer novel strategies for treating atherosclerosis (AS). These nanoparticles enhance drug delivery to lesion sites, improving therapeutic outcomes and reducing side effects in AS management.

Keywords:
ROS-responsive therapyatherosclerosisnanoparticlesreactive oxygen species (ROS)scavenger

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Atherosclerosis (AS) is a primary cause of mortality in developed nations, necessitating early prevention and effective treatments.
  • The long-term, asymptomatic nature of AS progression complicates management and highlights the need for innovative therapeutic approaches.
  • Reactive oxygen species (ROS) play a critical role in AS pathogenesis, making them a target for intervention.

Purpose of the Study:

  • To review the mechanisms of atherosclerosis and ROS generation/removal.
  • To explore the application of ROS-based nanoparticles (NPs) in AS therapy.
  • To summarize recent advances, challenges, and future directions for ROS-based NPs in treating AS.

Main Methods:

  • Literature review focusing on atherosclerosis mechanisms and ROS.
  • Analysis of ROS-based NPs for biomedical applications, including scavenging and drug delivery.
  • Synthesis of current research on nanoparticle-based therapeutic strategies for AS.

Main Results:

  • ROS-based NPs demonstrate potential for targeted drug delivery to atherosclerotic lesions.
  • These NPs can prolong therapeutic effects and enable controlled drug release, minimizing adverse side effects.
  • ROS-based NPs show promise as both diagnostic and therapeutic agents for AS.

Conclusions:

  • ROS-based nanoparticles represent a promising frontier in the treatment of atherosclerosis.
  • Further research into ROS-based NPs can lead to improved therapeutic strategies and better patient outcomes for AS.
  • Addressing current challenges and exploring future perspectives will optimize the clinical translation of ROS-based NPs for AS.