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In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
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Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

Germán J Medina-Rincón1, Sebastián Gallo-Bernal1,2,3, Paula A Jiménez4

  • 1School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia.

Pathogens (Basel, Switzerland)
|November 27, 2021
PubMed

Insights

Chagas disease, caused by Trypanosoma cruzi, leads to severe chronic cardiovascular and gastrointestinal issues. This review details parasite mechanisms, epidemiology, and current diagnosis and treatment challenges for this neglected tropical disease.

Area of Science:

  • Tropical Medicine and Infectious Diseases
  • Parasitology
  • Cardiovascular and Gastrointestinal Pathology

Background:

  • Chronic Chagas disease causes severe cardiovascular and gastrointestinal complications.
  • Accurate diagnosis and effective treatment for Trypanosoma cruzi infection remain challenging globally.
  • Understanding host-parasite interactions is crucial for managing Chagas disease.

Purpose of the Study:

  • To provide an updated review of Trypanosoma cruzi, the causative agent of Chagas disease.
  • To summarize the epidemiology, clinical manifestations, and diagnostic approaches for chronic Chagas disease.
  • To discuss current and potential treatment strategies for Chagas disease complications.

Main Methods:

  • Comprehensive literature review of peer-reviewed articles on Chagas disease.
  • Analysis of studies covering parasite biology, host-parasite interactions, and clinical aspects.
  • Synthesis of information on diagnostic tools and therapeutic interventions.

Main Results:

  • Detailed overview of Trypanosoma cruzi life cycle, genetic diversity, and virulence factors.
  • Description of the epidemiology and clinical spectrum of chronic Chagas disease.
  • Assessment of current diagnostic limitations and treatment options for chronic manifestations.

Conclusions:

  • Chagas disease poses significant health burdens due to its chronic, disabling effects.
  • Integrated approaches combining improved diagnostics and novel therapeutics are needed.
  • Further research into parasite biology and host response is essential for effective disease control.

Keywords:
Chagas diseaseTrypanosoma cruziachalasiacardiomyopathyheart failuremegacolonvector-borne disease

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