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Related Experiment Video

Updated: Oct 12, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

A Fast Bubble Detection Method in Microtubes Based on Pulsed Ultrasound.

Yiqing Li¹, Junwu Wu¹, Leijie Fu¹

¹School of Mechatronic Engineering, Xi'an Technological University, Xi'an 710021, China.

|November 27, 2021

Summary

This study presents a real-time microbubble detection method using pulsed ultrasound to improve microfluidic accuracy. The technique modifies liquid volume measurements, enhancing gauging precision in biological applications.

Keywords:

flow gauging accuracy microbubble pulsed-ultrasound two-phase flow

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Last Updated: Oct 12, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Area of Science:

Biomedical Engineering
Fluid Dynamics
Ultrasound Technology

Background:

Microbubbles in microfluidic devices significantly impair measurement accuracy.
Accurate liquid volume gauging is critical for biological manipulation and analysis.

Purpose of the Study:

To develop and validate a real-time microbubble detection and size estimation method.
To improve the gauging accuracy of microfluidic systems by compensating for bubble-induced errors.

Main Methods:

Development of a microbubble detector utilizing pulsed-ultrasound technology.
Derivation of microbubble assessment formulas based on two-phase theory and simulation.
Application of digital image processing for microbubble calibration.

Main Results:

The pulsed-ultrasound detector accurately estimates microbubble size in real time.
The method effectively modifies liquid volume measurements based on detected microbubbles.
Experimental validation confirms significant improvement in microflow gauging accuracy.

Conclusions:

The developed pulsed-ultrasound method offers an effective solution for mitigating microbubble errors in microfluidics.
This technique enhances the reliability and precision of biological microfluidic manipulation.
Real-time monitoring and compensation are key to accurate microflow gauging.