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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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Choroidal Volume Evaluation after Photodynamic Therapy Using New Optical Coherence Tomography Imaging Algorithm.

Miki Sato-Akushichi1, Shinji Ono1, Gerd Klose2

  • 1Department of Ophthalmology, Asahikawa Medical University, Asahikawa 078-8510, Japan.

Pharmaceuticals (Basel, Switzerland)
|November 27, 2021
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC) significantly reduces choroidal volume. This treatment also decreases choroidal volume in non-irradiated areas, indicating a systemic effect.

Keywords:
central serous chorioretinopathychoroidal thicknesschoroidal volumenew algorithmphotodynamic therapy

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Area of Science:

  • Ophthalmology
  • Medical Imaging

Background:

  • Chronic central serous chorioretinopathy (CSC) is a condition affecting the macula.
  • Photodynamic therapy (PDT) is a treatment option for chronic CSC.

Purpose of the Study:

  • To quantitatively evaluate changes in choroidal volume and thickness after PDT in chronic CSC patients.
  • To assess both irradiated and non-irradiated choroidal areas.

Main Methods:

  • Retrospective analysis of 14 chronic CSC patients who underwent PDT.
  • Measurement of choroidal volume and thickness at baseline, one month, and three months post-treatment.
  • Comparison with 9 healthy control subjects.

Main Results:

  • A significant decrease in mean choroidal volume was observed in CSC eyes post-PDT.
  • Choroidal volume reduction was noted in both central and peripheral (non-irradiated) areas.
  • The study demonstrated quantitative and qualitative choroidal changes using an algorithm.

Conclusions:

  • PDT effectively reduces choroidal volume in chronic CSC patients.
  • The observed decrease in non-irradiated areas suggests a potential systemic effect of PDT on choroidal vasculature.
  • Quantitative evaluation of choroidal changes is crucial for assessing treatment efficacy.