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PPARα Modulation-Based Therapy in Central Nervous System Diseases

Deokho Lee1,2, Yohei Tomita1,2,3, William Allen3

  • 1Laboratory of Photobiology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Life (Basel, Switzerland)
|November 27, 2021
PubMed

Insights

Peroxisome proliferator-activated receptors alpha (PPARα) show therapeutic potential for central nervous system (CNS) diseases. This review summarizes PPARα

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Global increase in neurodegenerative diseases affecting the central nervous system (CNS).
  • Inflammatory responses and metabolic derangements are key risk factors for CNS diseases.
  • Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors regulating cellular metabolism.

Purpose of the Study:

  • To comprehensively review the therapeutic roles of PPARα modulation in CNS diseases.
  • To highlight recent advances in PPARα's role in brain, spinal cord, and eye conditions.
  • To explore PPARα as a therapeutic target for preventing and treating CNS diseases.

Main Methods:

  • Literature review focusing on studies investigating PPARα modulation in CNS diseases.
  • Analysis of recent advances in understanding PPARα's mechanisms and therapeutic applications.
  • Synthesis of findings related to PPARα's impact on neuroinflammation and metabolic pathways.

Main Results:

  • PPARα modulation demonstrates significant therapeutic potential in preclinical and clinical studies for various CNS diseases.
  • PPARα influences key signaling pathways involved in neuroprotection, anti-inflammation, and metabolic homeostasis within the CNS.
  • Specific examples of PPARα's beneficial effects are detailed for conditions affecting the brain, spinal cord, and eye.

Conclusions:

  • PPARα represents a promising therapeutic target for managing and preventing neurodegenerative diseases.
  • Further research into PPARα modulation can lead to novel therapeutic strategies for CNS disorders.
  • This review provides a foundation for developing comprehensive approaches targeting PPARα.
Keywords:
central nervous systemeyeperoxisome proliferator-activated receptors

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